Oral Rehydration Solution (ORS) and WHO Recommended Formula

Introduction

Experts recommend WHO-approved ORS solutions is a scientifically formulated mixture of salts and sugars designed to prevent and treat dehydration caused by diarrhea and other conditions that lead to fluid loss. Recognized as one of the most significant medical advancements in public health, ORS has saved millions of lives worldwide. Biophar Group, a division of Biophar Lifesciences Pvt. Ltd., is committed to producing high-quality ORS solutions in adherence to the WHO-recommended formula, ensuring optimal rehydration and electrolyte balance for patients.

Understanding ORS

ORS is primarily used for the treatment of dehydration resulting from diarrhea, vomiting, or excessive sweating. It restores essential electrolytes and fluids lost from the body, making it a crucial intervention for various medical conditions. The effectiveness of ORS lies in its ability to promote the absorption of sodium and water through the intestinal lining, ensuring quick and efficient rehydration.

Diarrhea remains a leading cause of mortality in children under the age of five, particularly in developing countries. The administration of ORS has significantly reduced death rates by providing a simple, cost-effective solution to fluid loss. The widespread use of ORS has been instrumental in managing dehydration at home and in healthcare settings, reducing the burden on hospitals and medical professionals.

WHO Recommended ORS Formula

The World Health Organization (WHO) has set a standard formulation for ORS to ensure maximum efficacy. The composition includes:

• Glucose (anhydrous): 13.5 g
• Sodium chloride: 2.6 g
• Potassium chloride: 1.5 g
• Trisodium citrate dihydrate: 2.9 g
• Total osmolarity: 245 mOsm/L

This composition is scientifically proven to optimize the rehydration process and restore electrolyte balance in the body. It has a reduced osmolarity compared to earlier formulations, which significantly enhances sodium and water absorption while reducing the risk of hypernatremia.

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Benefits of ORS

1. Prevents Dehydration: ORS replenishes lost fluids and electrolytes, preventing severe dehydration that can lead to serious health complications.

2. Rapid Absorption: The presence of glucose aids in the quick absorption of sodium and water in the intestines, facilitating faster recovery.

3. Safe and Effective: ORS is a globally recognized treatment for dehydration and is considered one of the safest and most effective medical interventions. Experts recommend WHO-approved ORS solutions

4. Easily Accessible and Affordable: ORS is inexpensive and widely available, making it an accessible solution for dehydration treatment across all economic strata.

5. Reduces Mortality Rates: It has significantly reduced child mortality rates caused by diarrhea, particularly in developing countries.

6. No Need for Intravenous Therapy: ORS serves as a primary treatment option before resorting to intravenous rehydration, reducing hospitalization rates.

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How to Prepare ORS

To ensure effective treatment, ORS should be prepared correctly:

1. Dissolve one packet of WHO-recommended ORS in one liter of clean, potable water.
2. Stir well until the contents are fully dissolved.
3. Administer the solution in small sips to the patient throughout the day.
4. Discard any leftover solution after 24 hours to prevent contamination.

It is essential to use clean and safe drinking water to avoid introducing harmful bacteria that can worsen dehydration.

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ORS and Children

Children are particularly vulnerable to dehydration due to diarrhea and other infections. The WHO recommends administering ORS as follows:

• Infants (under 6 months): 30–50 ml per hour
• Children (6 months – 2 years): 50–100 ml per hour
• Children (2–5 years): 100–200 ml per hour

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Biophar Group’s Commitment to Quality

Biophar Group, a division of Biophar Lifesciences Pvt. Ltd., is dedicated to manufacturing WHO-recommended ORS formulations under strict quality control standards. The company ensures:

• High-Quality Ingredients: Using pharmaceutical-grade ingredients to maintain efficacy and safety.
• Stringent Manufacturing Processes: Adhering to Good Manufacturing Practices (GMP) to deliver premium products.
• Compliance with WHO and ISO Standards: Ensuring that all ORS products meet global health and safety benchmarks.
• Wide Distribution Network: Making ORS easily available in both urban and rural healthcare settings.

Conclusion

ORS is an essential tool in the fight against dehydration, significantly reducing morbidity and mortality rates worldwide. The WHO-recommended formula ensures effective and safe rehydration, and Biophar Group upholds this standard through its high-quality manufacturing processes. Whether for medical use, pediatric care, or general hydration, ORS remains a lifesaving solution available to all. Through continued awareness and accessibility, we can further the global impact of this simple yet powerful medical intervention.

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